Cell types can be distinguished by measuring their viscoelastic recovery times using a micro-fluidic device
نویسندگان
چکیده
منابع مشابه
Cell types can be distinguished by measuring their viscoelastic recovery times using a micro-fluidic device
We introduce a simple micro-fluidic device containing an actuated flexible membrane, which allows the viscoelastic characterization of cells in small volumes of suspension by loading them in compression and observing the cell deformation in time. From this experiment, we can determine the characteristic time constant of recovery of the cell. To validate the device, two cell types known to have ...
متن کاملMeasuring Cell Viscoelastic Properties Using a Microfluidic Extensional Flow Device.
The quantification of cellular mechanical properties is of tremendous interest in biology and medicine. Recent microfluidic technologies that infer cellular mechanical properties based on analysis of cellular deformations during microchannel traversal have dramatically improved throughput over traditional single-cell rheological tools, yet the extraction of material parameters from these measur...
متن کاملSmall cell lung cancer cell lines: pure and variant types can be distinguished by their extracellular matrix synthesis.
Variant subclasses of cell lines derived from small cell lung cancers have previously been characterized, having distinctive biochemical, morphological and growth properties compared to the classic lines. Both types of small cell lung cancer express features suggesting that they are derived from neuroectodermal cells. We compared the capacity of these two types of lung cancer cell lines to synt...
متن کاملmeasuring viscoelastic properties of Red Blood Cell using optical tweezers
Efforts have been made to study the behavior of complex materials in micrometer dimensions with various techniques. One of these methods is the use of optical tweezers for biophysical applications. Red blood cells, as the most abundant blood-forming cells, play an important role in the life of living organisms, and their unique mechanical properties are important. In this report, the study of s...
متن کاملFast Multi-objective Optimisation of a Micro-fluidic Device by Using Graphics Accelerators
The development of technology that uses widely available and inexpensive hardware for realworld cases is presented in this work. This is part of a long-term approach to minimise the impact of aviation on the environment and aims to enable the users both from industrial and academic background to design more optimal mixing devices. Here, a Multi-Objective Tabu Search is combined with a flow solv...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biomedical Microdevices
سال: 2010
ISSN: 1387-2176,1572-8781
DOI: 10.1007/s10544-010-9468-4